Promethazine with Codeine Oral Option ought to be utilised with caution in individuals with bone-marrow depression. Leukopenia and agranulocytosis have been described, typically when promethazine has actually been Employed in Affiliation with other regarded marrow-harmful agents.
Studies in Girls breastfeeding have shown hazardous infant results. A substitute for this medication really should be prescribed or you'll want to prevent breastfeeding although utilizing this drugs.
A perhaps fatal symptom complicated sometimes often called Neuroleptic Malignant Syndrome (NMS) has been claimed in association with promethazine HCl by yourself or in combination with antipsychotic medication.
Codeine and hydrocodone are opioid discomfort aid drugs that Medical professionals prescribe to take care of ache in selected circumstances. Hydrocodone is more robust than codeine and includes an increased probable for dependancy.
Drug interactions may possibly improve how your drugs get the job done or boost your chance for critical Negative effects. This doc would not consist of all attainable drug interactions.
In the event you think that you or a person close to you is exhibiting signs of dependancy, you may Get hold of the following corporations for fast enable and information:
The phosphate salt of codeine happens as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and slightly soluble in Alcoholic beverages. The molecular weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it has the next chemical construction.
Endocrine/Metabolic: Circumstances of serotonin syndrome, a perhaps lifestyle-threatening affliction, happen to be documented in the course of concomitant utilization of opioids with serotonergic medication.
Notify your medical professional For anyone who is Expecting or Consider you may well be Expecting. In the course of pregnancy, this solution just isn't advised. It could hurt an unborn newborn. Check with your doctor about the challenges and advantages of this medication. See also Warning area.
Prevent using Promethazine with Codeine Oral Option in clients with head injuries, intracranial lesions, or possibly a pre-present boost in intracranial pressure. In individuals who can be prone to the intracranial results of CO2 retention (e.
Maybe undertaking any range of interventions built to help Restrict the absorption in the drug in the body.
If a nursing mom is really an extremely-quick metabolizer of codeine, it could lead on to the morphine overdose while in the nursing infant and cause very major Unwanted effects.
All healthcare professionals are strongly proposed to accomplish the REMS instruction system and suggest individuals and their caregivers within the Harmless use and severe dangers connected to opioids determined by these parameters.[thirty] In the same way, the successful use from the Prescription Drug Checking Software (PDMP) can determine people who're probable liable to creating dependence and subsequent habit to opioids.
Promethazine with Codeine Oral Alternative just isn't advised for use in pregnant Girls. Prolonged utilization of Promethazine with Codeine Oral Alternative during pregnancy can lead to withdrawal while in the neonate. Neonatal opioid withdrawal syndrome, as opposed to opioid withdrawal syndrome in adults, could be lifestyle-threatening if not acknowledged and addressed, and requires management according to Promethazine codeine syrup protocols produced by neonatology gurus.